The article examines the potential of middle powers’ cooperation to establish communities of practice to reinforce their ability to influence world affairs. Illustrating the argument with three case studies—Australia, Indonesia, and South Korea—we assert that middle powers play key roles in structuring the world order. We test the following hypotheses: (i) middle powers do not look, nor do they need to look to great powers for leadership, and can influence events by forging new regional relationships; (ii) when leadership topples or tensions emerge between great powers, with a potential or nascent leadership vacuum, the initiative to guarantee the status quo (i.e., a liberal order) can be provided by middle powers. While rooted in IR theories, the research mostly builds upon the framework of communities of practice and management theories, linking them to highlight the importance of existing interactions, the opportunity for and advantage of greater cooperation and its potential systemic impact.