Prolonged propofol infusion for mechanically ventilated children
Copyright policy )Prolonged propofol infusion for mechanically ventilated children
Summary We retrospectively analysed 30‐day mortality and duration of intubation for 8016 children ventilated for three or more days, sedated with midazolam (n = 7716) or propofol (n = 300). We matched the propensity scores of 263 pairs of children. The propensity‐matched 30‐day mortality (95% CI ) was similar: 17/263 (6.5%) with midazolam vs. 24/263 (9.1%) with propofol, p = 0.26. Weaning from mechanical ventilation of children sedated with midazolam was slower than weaning of children sedated with propofol, subhazard ratio (95% CI ) 1.43 (1.18–1.73), p < 0.001.
- University of Tokyo Japan
- Institute of Science Tokyo Japan
- Jichi Medical University Japan
Male, Time Factors, Adolescent, Critical Care, Critical Illness, Midazolam, Infant, Respiration, Artificial, Treatment Outcome, Intubation, Intratracheal, Humans, Hypnotics and Sedatives, Female, Infusions, Intravenous, Propofol, Ventilator Weaning, Retrospective Studies
Male, Time Factors, Adolescent, Critical Care, Critical Illness, Midazolam, Infant, Respiration, Artificial, Treatment Outcome, Intubation, Intratracheal, Humans, Hypnotics and Sedatives, Female, Infusions, Intravenous, Propofol, Ventilator Weaning, Retrospective Studies
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