This paper presents a design of strong physical unclonable function (PUF) exploiting the sneak paths in the resistive X-point array. The entanglement of the sneak paths in the X-point array greatly enhances the entropy of the physical system, thereby increasing the space of challenge-response pairs. To eliminate the undesired collision or diffuseness in X-point PUF with “analog” resistance distribution and “digital” resistance distribution is employed in this paper. The effect of design parameters and non-ideal properties in X-point array on the performance of X-point PUF is systematically investigated by Simulation Program with Integrated Circuit Emphasis (SPICE) simulation. The simulation results show that—1) the PUF’s performance presents strong dependence on the percent of cells in the on-state, thus should be carefully optimized for the robustness against the reference current variation of the sense amplifier; 2) the interconnect resistance decreases the column current thus the reference current should scale down with the scaling of technology node; 3) larger on/off ratio is desired to achieve low power consumption and high robustness against reference current variation; and 4) the device-to-device variation might degrade the performance of X-point PUF, which can be mitigated with write-verify programming scheme in the PUF construction phase. In addition, the proposed X-point PUF presents no correlation between challenges and responses, and strong security against the possible SPICE modeling attack and machine learning attack. Compared with the conventional Arbiter PUF, the X-point PUF has benefits in smaller area, lower energy, and enhanced security.