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IEEE Transactions on Biomedical Engineering
Article . 2011 . Peer-reviewed
License: IEEE Copyright
Data sources: Crossref
DBLP
Article . 2020
Data sources: DBLP
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A Preliminary Model of Gastrointestinal Electromechanical Coupling

Authors: Du, P.; Poh, Y.C.; Lim, J.L.; Gajendiran, V.; Orgrady, G.; Buist, M.L.; Pullan, A.J.; +1 Authors

A Preliminary Model of Gastrointestinal Electromechanical Coupling

Abstract

Gastrointestinal (GI) motility is coordinated by several cooperating mechanisms, including electrical slow wave activity, the enteric nervous system (ENS), and other factors. Slow waves generated in interstitial cells of Cajal (ICC) depolarize smooth muscle cells (SMC), generating basic GI contractions. This unique electrical coupling presents an added layer of complexity to GI electromechanical models, and a current barrier to further progress is the lack of a framework for ICC-SMC-contraction coupling. In this study, an initial framework for the electromechanical coupling was developed in a 2-D model. At each solution step, the slow wave propagation was solved first and [Ca(2+)](i) in the SMC model was related to a Ca(2+)-tension-extension relationship to simulate active contraction. With identification of more GI-specific constitutive laws and material parameters, the ICC-SMC-contraction approach may underpin future GI electromechanical models of health and disease states.

Country
Singapore
Keywords

600, Muscle, Smooth, smooth muscle cells (SMC), Interstitial Cells of Cajal, Mechanotransduction, Cellular, Models, Biological, 620, Electrophysiological Phenomena, Gastrointestinal Tract, slow waves, motility, Bidomain, interstitial cells of Cajal (ICC), Humans, Calcium, Gastrointestinal Motility

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    selected citations
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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    21
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
21
Top 10%
Average
Average
bronze