A study of siting considerations for possible future accelerators at Fermilab is underway. Each candidate presents important challenges in environment, safety, and health (ES&H) that are reviewed generically in this paper. Some of these considerations are similar to those that have been encountered and solved during the construction and operation of other accelerator facilities. Others have not been encountered previously on the same scale. The novel issues will require particular attention coincident with project design efforts to assure their timely cost-effective resolution. It is concluded that with adequate planning, the issues can be addressed in a manner that merits the support of the Laboratory, the U.S. Department of Energy (DOE), and the public.