Image registration is enabling in integrating complementary and heterogeneous information from multiple images, and is particularly important for high-quality healthcare. To improve registration efficiency and accuracy, in this paper, a two-resolution-scale registration approach is proposed. Firstly, to speed up calculation, the images will be decomposed into multi-scale and multi-band representation by steerable pyramid that outweighs wavelets by providing invariance for both translation and rotation. Then, to avoid transformation error accumulation and magnification during the parameter transmission in the traditional multi-scale registration, the registration will be performed only in the lowest-resolution scale and the highest-resolution scale. In the former scale, the global rotation and scaling parameters will be calculated rapidly and accurately, which then will be directly used to initialize optimization in the latter scale, where, the translation differences will be corrected. The experiments on medical images demonstrate that the proposed registration is of good performance.