In this paper, the radial pulse waveforms of the same subjects under various contact pressures were measured. Then, the feature points of the pulse wave contours were extracted and the physical parameters were calculated corresponding to different contact pressures. The various trends of parameters, including peripheral augmentation index, peripheral subendocardial viability ratio, and peripheral resistance, influenced by contact pressures were analyzed. By comparing the variation trend between different subject groups, it is notable that there exists a significant difference between the parameters of young healthy people and elder patients (P<0.01). Moreover, the peripheral augmentation index, SEVR and the peripheral resistance descend with increased contact pressure, because of the variation of pulse wave contour.