Gardner's multiple intelligence theory provides a new thought for the colleges' cultivation of talents by its rich educational content. The multiple intelligence theory enlightens us that the intelligence structure of the creative talents is an integrated system where various intelligence essential factors are realigned, maintaining close ties with each other and make the mode of thinking diversified. In this paper, in view of the problems in the talents training of computer professional, we combine multiple intelligence theory with the characteristics of computer science to optimize instructional design, condense course content, create multi-intelligence development environment, implement effective teaching method and teaching means and adopt variety of evaluation methods to cultivate student's comprehensive ability.