We study the problem of matrix isomorphism of matrix Lie algebras (MatIsoLie). Lie algebras arise centrally in areas as diverse as differential equations, particle physics, group theory, and the Mulmuley -- Sohoni Geometric Complexity Theory program. A matrix Lie algebra is a set L of matrices that is closed under linear combinations and the operation [A, B] = AB - BA. Two matrix Lie algebras L, L' are matrix isomorphic if there is an invertible matrix M such that conjugating every matrix in L by M yields the set L'. We show that certain cases of MatIsoLie -- for the wide and widely studied classes of semi simple and abelian Lie algebras -- are equivalent to graph isomorphism and linear code equivalence, respectively. On the other hand, we give polynomial-time algorithms for other cases of MatIsoLie, which allow us to mostly derandomize a recent result of Kayal on affine equivalence of polynomials.