This paper gives a method to simulate the shielded cable in PSpice. The multiconductor transmission line theory is applied to deal with the cable system. The influence of the grounding conditions on the shielding effect is studied. Through simulations, it is observed that imperfect grounding of the shield can lead different cross-talk in the inner cable. Losing grounding at near-end or far-end of shield gives different impacts on near-end cross-talk. What is more, when one end of the shield is open the cross-talk may be severer than that when both ends of shield are open. The reasons for different cross-talk according to different kinds of imperfect grounding are discussed. By comparison the different voltage responses, advices for better shielding effect are drawn.