A low supply-dependence fully-MOSFET voltage reference for low-voltage and low-power is presented. It compensates for the temperature dependence of a current based on gate-source voltage of a MOSFET operating in subthreshold region with a low supply-dependence PTAT current, and exhibits very low supply-dependence for supply voltage. The SPICE simulation demonstrated that with a power supply voltage of 1.0 V, this circuit exhibits an output voltage of 298 mV with a temperature coefficient of 72.6 ppm/degC in the range from -23degC to 77degC, and extremely low supply-dependence of 20.4 muV/V in the supply voltage range from 1 V to 5 V. The total power supply current is 1.48 muA. Therefore, the proposed circuit would be very suitable for a low-voltage and low-power application in an environment where the temperature and power supply voltage change.