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SELVa: Simulator of Evolution with Landscape Variation

Authors: Elena Nabieva; Georgii A. Bazykin;

SELVa: Simulator of Evolution with Landscape Variation

Abstract

Organisms evolve to increase their fitness, a process that may be described as climbing the fitness landscape. However, the fitness landscape of an individual site, i.e., the vector of fitness values corresponding to different variants at this site, can change with time due to changes in the environment or substitutions at other epistatically interacting sites. We present SELVa, the Simulator of Evolution with Landscape Variation, aimed at modeling the substitution process under a changing single position fitness landscape in a set of evolving lineages forming a phylogeny of arbitrary shape. Written in Java and distributed as an executable jar file, SELVa provides a flexible framework that allows the user to choose from a number of implemented rules governing landscape change. Availability https://github.com/bazykinlab/SELVa

Keywords

Genotype, Models, Genetic, Science, Q, R, Biological Evolution, Mutation, Medicine, Humans, Genetic Fitness, Phylogeny, Software, Research Article

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    influence
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
3
Average
Average
Average
Green
gold