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Cophylogeny Reconstruction via an Approximate Bayesian Computation

Authors: Baudet, C.; DONATI, BEATRICE; Sinaimeri, B.; CRESCENZI, PIERLUIGI; Gautier, C.; Matias, C.; Sagot, M. F.;
APC: 1,300 EUR

Cophylogeny Reconstruction via an Approximate Bayesian Computation

Abstract

Despite an increasingly vast literature on cophylogenetic reconstructions for studying host-parasite associations, understanding the common evolutionary history of such systems remains a problem that is far from being solved. Most algorithms for host-parasite reconciliation use an event-based model, where the events include in general (a subset of) cospeciation, duplication, loss, and host switch. All known parsimonious event-based methods then assign a cost to each type of event in order to find a reconstruction of minimum cost. The main problem with this approach is that the cost of the events strongly influences the reconciliation obtained. Some earlier approaches attempt to avoid this problem by finding a Pareto set of solutions and hence by considering event costs under some minimization constraints. To deal with this problem, we developed an algorithm, called Coala, for estimating the frequency of the events based on an approximate Bayesian computation approach. The benefits of this method are 2-fold: (i) it provides more confidence in the set of costs to be used in a reconciliation, and (ii) it allows estimation of the frequency of the events in cases where the data set consists of trees with a large number of taxa. We evaluate our method on simulated and on biological data sets. We show that in both cases, for the same pair of host and parasite trees, different sets of frequencies for the events lead to equally probable solutions. Moreover, often these solutions differ greatly in terms of the number of inferred events. It appears crucial to take this into account before attempting any further biological interpretation of such reconciliations. More generally, we also show that the set of frequencies can vary widely depending on the input host and parasite trees. Indiscriminately applying a standard vector of costs may thus not be a good strategy.

Countries
France, France, Italy, France, France
Keywords

[SDV.BID.SPT]Life Sciences [q-bio]/Biodiversity/Systematics, cophylogeny, Host-Parasite Interactions, approximate Bayesian computation, [STAT.AP] Statistics [stat]/Applications [stat.AP], likelihood-free inference, [SDV.BID.SPT] Life Sciences [q-bio]/Biodiversity/Systematics, Phylogenetics and taxonomy, Approximate Bayesian computation, cophylogeny, host/parasite systems, likelihood-free inference, Animals, Arthropods, Phylogeny, [INFO.INFO-BI] Computer Science [cs]/Bioinformatics [q-bio.QM], [STAT.AP]Statistics [stat]/Applications [stat.AP], host/parasite systems, Bayes Theorem, Phylogenetics and taxonomy, approximate Bayesian computation; cophylogeny; host/parasite systems; likelihood-free inference; Animals; Arthropods; Bayes Theorem; Classification; Host-Parasite Interactions; Wolbachia; Algorithms; Phylogeny; Ecology, Evolution, Behavior and Systematics; Genetics; Medicine (all), Classification, 004, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], Algorithms, Wolbachia, Regular Articles

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
30
Top 10%
Top 10%
Top 10%
Green
hybrid