
pmid: 16221895
Many families of interspersed repetitive DNA elements, including human Alu and LINE (Long Interspersed Element) elements, have been proposed to have accumulated through repeated copying from a single source locus: the "master gene." The extent to which a master gene model is applicable has implications for the origin, evolution, and function of such sequences. One repetitive element family for which a convincing case for a master gene has been made is the rodent ID (identifier) elements. Here we devise a new test of the master gene model and use it to show that mouse ID element sequences are not compatible with a strict master gene model. We suggest that a single master gene is rarely, if ever, likely to be responsible for the accumulation of any repeat family.
Evolution, Molecular, Long Interspersed Nucleotide Elements, Models, Genetic, Alu Elements, Quantitative Trait Loci, Gene Dosage, Animals, Humans
Evolution, Molecular, Long Interspersed Nucleotide Elements, Models, Genetic, Alu Elements, Quantitative Trait Loci, Gene Dosage, Animals, Humans
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