ABSTRACT The ability to test and constrain theories of cosmic inflation will advance substantially over the next decade. Key data sources include cosmic microwave background (CMB) measurements and observations of the distribution of matter at low-redshift from optical, near-infrared, and 21-cm intensity surveys. A positive detection of a CMB B-mode consistent with a primordial stochastic gravitational wave background (SGWB) is widely viewed as a smoking gun for an inflationary phase. Still, a null result does not exclude inflation. However, in a significant class of inflationary scenarios, a low SGWB amplitude is correlated with a more significant running, αs, in the primordial density perturbations than is seen with the simplest inflationary potentials. With this motivation, we forecast the precision with which the spectral index ns and αs can be constrained by currently envisaged observations, including CMB (Simons Observatory, CMB-S4 and LiteBIRD), optical/near infra-red (DESI and SPHEREx), and 21-cm intensity mapping (Tianlai and CHIME) surveys. We identify optimal combinations of data sets for constraining the running and show that they may yield additional and informative constraints on the overall inflationary parameter space if the SGWB remains undetected.