Misophonia is a recently described condition that is marked by extreme adverse reactions to select classes of trigger sounds. It has recently received attention as a putative diagnosable condition, and specifically as a member of the class of obsessive-compulsive and related disorders. Adverse reactions may include physiological responses, emotional responses, and behaviors. Common trigger sounds include gustatory and respiratory noises and other sounds created by humans but vary widely among affected individuals. This chapter describes misophonia, including coverage of other audiological conditions that need to be ruled out in potential cases, the current state of assessment, and brief consideration of treatment approaches. Future clinical and research directions are highlighted.