The ductus arteriosus has a significant role in the fetal circulation connecting the main pulmonary artery to the aorta. Normally, after birth, it functionally closes within few hours but complete obliteration occurs at 2 to 3 weeks of age. Failure of the ductus arteriosus to close leads to the condition patent ductus arteriosus. This may be an isolated condition or associated with other congenital cardiac anomalies. Untreated patent ductus arteriosus may be a cause for failure to thrive and pose a risk for infective endocarditis. Management may include pharmacotherapy, nonsurgical closure, and surgical closure. Nonsurgical closure entails using the transcatheter technique. The surgical correction, via a left thoracotomy incision, may be done in the neonatal intensive care unit as a bedside procedure or in the operating room. The anesthetic management is challenging and may depend on the type of intervention.