Wistar Diabetic Fatty Rat

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1990 English Publisher:Oxford University Press (OUP)Journal:ILAR Journal, volume 32, pages 9-13 (issn: 1084-2020,

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Authors: R. Kava; R. G. Peterson; D. B. West; M. R. C. Greenwood;

doi: 10.1093/ilar.32.3.9

Wistar Diabetic Fatty Rat

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Abstract

Wistar diabetic fatty (WDF/Ta-/a) rats were developed by Ikeda et al. (1981) to provide a rat model of non-insulindependent diabetes mellitus (NIDDM). Human NIDDM is typically characterized by adult onset and varying degrees of obesity, hyperglycemia, hyperinsulinemia, insulin resistance, glucose intolerance, and peripheral neuropathy. To produce a model demonstrating such characteristics, these investigators crossed the genetically obese Zucker (fa/fa) rat with the somewhat carbohydrate-intolerant lean Wistar Kyoto rat. H. Ikeda and T. Matsuo of the Takeda Chemical Industries have kindly provided the following detailed history of the resulting WDF/Ta-/a strain:

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