Minimum alveolar concentration (MAC) of xenon in intubated swine

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2004 English Publisher:Elsevier BVJournal:British Journal of Anaesthesia, volume 92, pages 421-424 (issn: 0007-0912,

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Authors: K E, Hecker; N, Horn; J H, Baumert; S M, Reyle-Hahn; N, Heussen; R, Rossaint;

doi: 10.1093/bja/aeh077

pmid: 14742330

Minimum alveolar concentration (MAC) of xenon in intubated swine

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Abstract

The minimum alveolar concentration (MAC) is a traditional index of the hypnotic potency of an inhalational anaesthetic. To investigate the anaesthetic as well as the unwanted effects of xenon (Xe) in a swine model, it is useful to know MAC(Xe).The study was performed using ten swine (weight 27.8-35.4 kg) anaesthetized with halothane and Xe 0, 15, 30, 40, 50 and 65% in oxygen. With each Xe concentration, various concentrations of halothane were administered in a step-by-step design. For each combination, a supramaximal pain stimulus (claw clamp) was applied and the appearance of a withdrawal reaction was recorded. The MAC(Xe) with halothane was calculated using a logistic regression model.During stable ventilation, haemodynamics and temperature, MAC(Xe) value was determined as 119 vol. % (95% confidence limits 103-135).MAC(Xe) in swine was calculated by extrapolation of a logistic regression model. Its theoretical value is 119 vol. %.

Related Organizations

RWTH Aachen University
Germany

Keywords

Pain Threshold, Xenon, Dose-Response Relationship, Drug, Swine, Anesthetics, Combined, Logistic Models, Anesthesia, Closed-Circuit, Anesthetics, Inhalation, Intubation, Intratracheal, Animals, Female, Halothane

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