We provide a complete solution to the problem of extending a local Lie groupoid to a global Lie groupoid. First, we show that the classical Mal’cev’s theorem, which characterizes local Lie groups that can be extended to global Lie groups, also holds in the groupoid setting. Next, we describe a construction that can be used to obtain any local Lie groupoid with integrable algebroid. Last, our main result establishes a precise relationship between the integrability of a Lie algebroid and the failure in associativity of a local integration. We give a simplicial interpretation of this result showing that the monodromy groups of a Lie algebroid manifest themselves combinatorially in a local integration, as a lack of associativity.