It is well-known that the mean curvature flow is a formal gradient flow of the perimeter functional. However, by the work of Michor and Mumford [Doc. Math. 10 (2005), 217–245; J. Eur. Math. Soc. (JEMS) 8 (2006), 1–48], the formal Riemannian structure that is compatible with the gradient flow structure induces a degenerate metric on the space of hypersurfaces. It is then natural to ask whether there is a nondegenerate metric space of hypersurfaces, on which the mean curvature flow admits a gradient flow structure. In this paper we study the mean curvature flow on two nondegenerate metric spaces of simple closed plane curves: the uniformness-preserving metric structure proposed by Shi and Vorotnikov [J. Geom. Anal. 29 (2019), 3055–3097] and the curvature-weighted structure proposed by Michor and Mumford [J. Eur. Math. Soc. (JEMS) 8 (2006), 1–48], and prove that the mean curvature flow is not a gradient flow in either of the spaces.