Detection of Alpaca Podoplanin by Immunohistochemistry Using the Antibovine Podoplanin Monoclonal Antibody PMab-44
Copyright policy )Detection of Alpaca Podoplanin by Immunohistochemistry Using the Antibovine Podoplanin Monoclonal Antibody PMab-44
Podoplanin (PDPN) is expressed in type I alveolar cells of the lungs, lymphatic endothelial cells, and podocytes of the kidneys, and induces platelet aggregation through the C-type lectin-like receptor-2. PDPNs of various animal species have been characterized using specific anti-PDPN monoclonal antibodies (mAbs). However, alpaca PDPN has not previously been characterized because antialpaca PDPN mAbs have not yet been developed. In this study, we investigated the potential cross-reaction between established antibovine PDPN mAbs and alpaca PDPN. Using immunohistochemical analysis, type I alveolar cells of the alpaca lungs were detected by the antibovine PDPN mAb, PMab-44. These results indicate that PMab-44 may be useful for the detection of alpaca PDPN.
- Hokkaido Bunkyo University Japan
- Tohoku University Japan
- Hokkaido University Japan
Epitopes, Membrane Glycoproteins, Antibody Specificity, Immunochemistry, Animals, Antibodies, Monoclonal, Cattle, Camelids, New World
Epitopes, Membrane Glycoproteins, Antibody Specificity, Immunochemistry, Animals, Antibodies, Monoclonal, Cattle, Camelids, New World
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