
pmid: 28686462
Designing probabilistic reaction models and determining their stochastic kinetic parameters are major issues in systems biology. To assist in the construction of reaction network models, we introduce a logic that allows one to express asymptotic properties about the steady-state stochastic dynamics of a reaction network. Basically, the formulas can express properties on expectancies, variances, and covariances. If a formula encoding for experimental observations on the system is not satisfiable, then the reaction network model can be rejected. We demonstrate that deciding the satisfiability of a formula is NP-hard, but we provide a decision method based on solving systems of polynomial constraints. We illustrate our method on a toy example.
logic, Stochastic Processes, Models, Statistical, Markov chains, Systems Biology, 510, 004, Kinetics, Models, Chemical, Humans, steady state, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], constraints, Algorithms, Metabolic Networks and Pathways, stochastic modeling, [INFO.INFO-BI] Computer Science [cs]/Bioinformatics [q-bio.QM]
logic, Stochastic Processes, Models, Statistical, Markov chains, Systems Biology, 510, 004, Kinetics, Models, Chemical, Humans, steady state, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], constraints, Algorithms, Metabolic Networks and Pathways, stochastic modeling, [INFO.INFO-BI] Computer Science [cs]/Bioinformatics [q-bio.QM]
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