Abstract In modern society, there is an increasing tendency to innovate and start new talents, especially in medical laboratory science. At present, we need to study how to strengthen personnel training. The current teaching methods mainly include traditional manual teaching and network teaching. Medical laboratory science mainly uses PBL teaching, we conducted group experiments for these two teaching methods. The results show that the practice effect of the PBL teaching group is significantly improved compared with the traditional teaching group, but there was no obviously difference between the two groups in terms of theoretical performance. The results show that network and computer technology can significantly improve the quality of medical laboratory practice teaching and professional level of students.