I review the arguments in favor of/against the traditional hypothesis that the Planck, string and compactification scales are all within a couple of orders of magnitude from each other. I explain how the extreme brane-world scenario, with TeV type I scale and two large (near millimetric) transverse dimensions, creates conditions analogous to those of the energy desert and is thus naturally singled out. I comment on the puzzle of gauge coupling unification in this context.

Talk given at the Strings 99 Conference (Potsdam, July 1999), latex file (9 pages), uses ioplppt.sty