Observations are reported of optical interstellar absorption lines of Ti II, Ca II, and Na I in the spectrum of HD 14633, a probable runaway O star ejected from the Perseus spiral arm. Unusually high gas-phase abundances of the normally depleted elements Ca and Ti are found in three high-velocity interstellar line components; the light paths to only a few other stars are known to show a comparably strong Routly-Spitzer effect. The greatly reduced heavy-element depletions in these parcels of gas presumably reflect the disruption of interstellar grains in gas which may be located in the lower galactic halo at an absolute value of 2 of about 1 kpc.