No ATG8s, no problem? How LC3/GABARAP proteins contribute to autophagy
Copyright policy )No ATG8s, no problem? How LC3/GABARAP proteins contribute to autophagy
The ATG8 family LC3/GABARAP proteins are attached to the membrane of nascent autophagosomes, but their functions during autophagy are unclear. In this issue, Nguyen et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201607039) show that LC3/GABARAP proteins are not essential for autophagosome formation but are critical for autophagosome–lysosome fusion.
- University of Vienna Austria
- Max F. Perutz Laboratories Austria
LC3C, 106002 Biochemie, 106002 Biochemistry, Autophagy-Related Protein 8 Family, Models, Biological, Mitochondria, FUSION, Phagosomes, KINASE, Commentary, Autophagy, Animals, Humans, TRAFFICKING, SELECTIVE AUTOPHAGY, 106052 Zellbiologie, 106052 Cell biology, Microtubule-Associated Proteins, SYSTEM, Adaptor Proteins, Signal Transducing, HeLa Cells
LC3C, 106002 Biochemie, 106002 Biochemistry, Autophagy-Related Protein 8 Family, Models, Biological, Mitochondria, FUSION, Phagosomes, KINASE, Commentary, Autophagy, Animals, Humans, TRAFFICKING, SELECTIVE AUTOPHAGY, 106052 Zellbiologie, 106052 Cell biology, Microtubule-Associated Proteins, SYSTEM, Adaptor Proteins, Signal Transducing, HeLa Cells
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