
pmid: 16022165
Adjustment for prognostic covariates is recommended in clinical trials because relative to a t-test, it improves precision and adjusts for treatment imbalances caused by an "unlucky" randomization. But, inclusion of too many covariates can be counterproductive. In the quest to strike a balance between inclusion of all important variables and not going overboard, people have proposed methods such as stepwise regression, whereby the decision to include a covariate depends on post-randomization data. Covariate inclusion decisions are typically based on either the strength of its correlation with the outcome or the degree of treatment imbalance. Are these methods valid? Is there a valid way to analyze such data? These are some of the questions we address.
Random Allocation, Research Design, Data Interpretation, Statistical, Prognosis, Algorithms
Random Allocation, Research Design, Data Interpretation, Statistical, Prognosis, Algorithms
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