Abstract A suspected inherited form of rickets was diagnosed in Corriedale sheep on a commercial sheep farm in Marlborough. Affected lambs were normal at birth but showed a reduced growth rate and a range of skeletal abnormalities, including both varus and valgus deformities and a characteristic dip in the shoulder region. Up to 20 affected lambs had been born on the property over the last two seasons. Skeletal lesions in affected lambs included swollen costochondral junctions, moderate to marked thickening of physes in long bones, and collapse of weakened subchondral bone, particularly in the proximal humerus. These lesions, together with the microscopic changes, strongly suggested a diagnosis of rickets. Affected lambs were hypocalcaemic and hypophosphataemic, consistent with a deficiency of vitamin D. Vitamin D assays revealed significantly higher 1,25(OH) vitamin D concentrations in affected lambs than in controls, suggesting a defect in the vitamin D receptor as the likely mechanism. DNA testing reve...