Drug-induced epidermolysis bullosa acquisita with antibodies to type VII collagen
Copyright policy )Drug-induced epidermolysis bullosa acquisita with antibodies to type VII collagen
We describe a 73-year-old patient who had a subepidermal bullous eruption develop after a course of antibiotics, including vancomycin. The patient had deposits of IgA and IgG in the cutaneous basement membrane zone that were located on the dermal side of 1 M NaCl-treated autologous skin. By an enzyme-linked immunosorbent assay, the patient was found to have circulating IgG antibodies directed against type VII collagen, the target antigen of epidermolysis bullosa acquisita. Our observation expands the spectrum of immune-mediated subepidermal bullous skin eruptions precipitated by drugs and lends support to the idea that a subset of these cases represents an unusual variant of drug-triggered epidermolysis bullosa acquisita.
- University Hospital of Geneva Switzerland
- University of Geneva Switzerland
Epidermolysis Bullosa Acquisita/chemically induced/immunology/pathology, Surgical Wound Infection/prevention & control, Gentamicins/administration & dosage/adverse effects, Enzyme-Linked Immunosorbent Assay, Adenocarcinoma, Epidermolysis Bullosa Acquisita, Vancomycin, 616, 617, Humans, Surgical Wound Infection, Pancreatic Neoplasms/drug therapy/surgery, Vancomycin/administration & dosage/adverse effects, Infusions, Intravenous, Aged, Autoantibodies, Adenocarcinoma/drug therapy/surgery, Collagen/immunology, Biopsy, Needle, Pancreatic Neoplasms, Fluorescent Antibody Technique, Direct, Collagen, Gentamicins, Autoantibodies/immunology, Follow-Up Studies
Epidermolysis Bullosa Acquisita/chemically induced/immunology/pathology, Surgical Wound Infection/prevention & control, Gentamicins/administration & dosage/adverse effects, Enzyme-Linked Immunosorbent Assay, Adenocarcinoma, Epidermolysis Bullosa Acquisita, Vancomycin, 616, 617, Humans, Surgical Wound Infection, Pancreatic Neoplasms/drug therapy/surgery, Vancomycin/administration & dosage/adverse effects, Infusions, Intravenous, Aged, Autoantibodies, Adenocarcinoma/drug therapy/surgery, Collagen/immunology, Biopsy, Needle, Pancreatic Neoplasms, Fluorescent Antibody Technique, Direct, Collagen, Gentamicins, Autoantibodies/immunology, Follow-Up Studies
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