For the global performance of monopile wind farms, the desired wave field distribution using traditional layout methods is hard to obtain. In this study, the investigation aims to efficiently explore the potential wave response reduction of the multiple layer design of wind farm layouts using novel grating conditions. It is very important and necessary to optimize the layouts of monopile-supported OWTs (offshore wind turbines) by analyzing the wave field performance, especially considering scour protection and avoiding the proximity of the wave frequency to natural frequency of OWTs. This paper presents a layout and a design method of monopile-supported OWTs using combined grating theorems, which can take space modulation into account to deal with various issues in existing layouts. The results show that the present method can modulate the wave field responses more evenly than the conventional cases. More specifically, total wave field distribution sensitivities were discussed under different wavelengths, amplitudes, layouts, pile-radius, and the angles of incident waves. It can be illustrated that the monopile-supported OTWs with sinusoidal configurations can have more modulation effects on wave fields in an appropriate wavelength band. As indicated, this method not only provides wave space modulation control but also sheds light on the wave field reduction mechanisms.