This paper presents the safety program conducted to determine the response of the General Purpose Heat Source (GPHS) Radioisotope Thermoelectric Generator (RTG) to potential launch accidents of the Space Shuttle for the Galileo and Ulysses missions. The National Aeronautics and Space Administration (NASA) provided definition of the Shuttle potential accidents and characterized the environments. The Launch Accident Scenario Evaluation Program (LASEP) was developed by GE to analyze the RTG response to these accidents. RTG detailed response to Solid Rocket Booster (SRB) fragment impacts, as well as to other types of impact, was obtained from an extensive series of hydrocode analyses. A comprehensive test program was conducted also to determine RTG response to the accident environments. The hydrocode response analyses coupled with the test data base provided the broad range response capability which was implemented in LASEP.