Low-temperature physics and astronomy have traditionally focused on developing exquisitely sensitive single‐pixel detectors. While this has yielded considerable results, these technologies almost uniformly suffer from an inability to scale to large array sizes. In order to circumvent this barrier, frequency-multiplexing techniques have recently emerged as a suitable solution. Here we present a detailed description of a measurement platform based on frequency-multiplexed superconducting resonators along with the results from two distinct measurements that leverage this nascent technology to achieve multiple-device readout. The first application discussed is a seven-pixel array sensor of the permittivity of liquid helium suitable for quantum hydrodynamic experiments. The second implementation described is a prototype 16-channel mm-wavelength detector optimized for ground-based astronomical detection at the 30 meter Institute for Millimeter-Wave Radio Astronomy (IRAM) telescope in Pico Veleta, Spain.