
NDOTHELIN-1 (ET-1) is a 21-amino acid peptide with an order of magnitude greater vasoconstrictive potency than any known endogenous compound. Since its discovery one decade ago, more than 1,500 publications have examined the role of endothelins in the development and maintenance of primary and secondary hypertension. Evidence indicates that neither plasma ET-1 levels nor vascular responsiveness to ET-1 correlate with blood pressure in most experimental models of hypertension and in patients with
Endothelin-1, Sodium, Sodium, Dietary, Blood Pressure, Rats, Mice, Body Water, Rats, Inbred SHR, Hypertension, Animals, Homeostasis, Humans, Kidney Tubules, Collecting
Endothelin-1, Sodium, Sodium, Dietary, Blood Pressure, Rats, Mice, Body Water, Rats, Inbred SHR, Hypertension, Animals, Homeostasis, Humans, Kidney Tubules, Collecting
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