A multichannel high‐resolution single‐slope analogue‐to‐digital converter (SS ADC) is presented that automatically compensates for process, voltage and temperature variations, as well as for radiation effects, in order to be used in extreme environmental conditions. The design combines an efficient implementation by using a feedback loop that ensures an inherently monotonic and very accurate ramp generation, with high levels of configurability in terms of resolution and conversion rate, as well as input voltage range. The SS ADC was designed in a standard 0.35 µm CMOS technology. Experimental measurements of the performance and stability against radiation and temperature are presented to verify the proposed approach.