Histone variants and lipid metabolism
Copyright policy )Histone variants and lipid metabolism
Within nucleosomes, canonical histones package the genome, but they can be opportunely replaced with histone variants. The incorporation of histone variants into the nucleosome is a chief cellular strategy to regulate transcription and cellular metabolism. In pathological terms, cellular steatosis is an abnormal accumulation of lipids, which reflects impairment in the turnover of triacylglycerols, affecting any organ but mainly the liver. The present review aims to summarize the experimental evidence for histone variant functions in lipid metabolism.
- University College London United Kingdom
- University Medical Center Groningen Netherlands
- Royal Free London NHS Foundation Trust United Kingdom
- Radboud University Nijmegen Netherlands
- The Royal Free Hospital United Kingdom
CHROMATIN, H3.3, Epigenesis, Genetic, Histones, MATERNAL OBESITY, Non-alcoholic Fatty Liver Disease, lipid metabolism, BINDING, steatosis, Animals, Humans, Protein Isoforms, HEPATIC STEATOSIS, FATTY LIVER-DISEASE, histone variant, MACROH2A1, nucleosome, Radboudumc 11: Renal disorders RIMLS: Radboud Institute for Molecular Life Sciences, Lipid Metabolism, EPIGENETICS, Nucleosomes, GENOME, MICE, Alternative Splicing, Gene Expression Regulation, Liver, gene expression
CHROMATIN, H3.3, Epigenesis, Genetic, Histones, MATERNAL OBESITY, Non-alcoholic Fatty Liver Disease, lipid metabolism, BINDING, steatosis, Animals, Humans, Protein Isoforms, HEPATIC STEATOSIS, FATTY LIVER-DISEASE, histone variant, MACROH2A1, nucleosome, Radboudumc 11: Renal disorders RIMLS: Radboud Institute for Molecular Life Sciences, Lipid Metabolism, EPIGENETICS, Nucleosomes, GENOME, MICE, Alternative Splicing, Gene Expression Regulation, Liver, gene expression
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