Physiological roles of the pantothenate kinases

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2014 English Publisher:Portland Press Ltd.Journal:Biochemical Society Transactions, volume 42, pages 1,033-1,036 (issn: 0300-5127, eissn: 1470-8752,

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Authors: Lorraine E, Dansie; Stacy, Reeves; Karen, Miller; Stephen P, Zano; Matthew, Frank; Caroline, Pate; Jina, Wang; +1 Authors

doi: 10.1042/bst20140096

pmid: 25109998

pmc: PMC4948118

Physiological roles of the pantothenate kinases

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Abstract

CoA (coenzyme A) is an essential cofactor that is involved in many metabolic processes. CoA is derived from pantothenate in five biosynthetic reactions. The CoA biosynthetic pathway is regulated by PanKs (pantothenate kinases) and four active isoforms are expressed in mammals. The critical physiological functions of the PanKs are revealed by systematic deletion of the Pank genes in mice.

Related Organizations

St. Jude Children's Research Hospital
United States

Keywords

Mice, Phosphotransferases (Alcohol Group Acceptor), Animals, Protein Isoforms, Coenzyme A, Mitochondria

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