descriptionPublicationkeyboard_double_arrow_right Article 29 Jan 2013 English Publisher:Portland Press Ltd.Journal:Biochemical Society Transactions, volume 41, pages 180-184 (issn: 0300-5127, eissn: 1470-8752,

Authors: Barwell, James; Wheatley, Mark; Conner, Alex C; Taddese, Bruck; Vohra, Shabana; Reynolds, Christopher A; Poyner, David R;

doi: 10.1042/bst20120251

pmid: 23356280

The activation of the CGRP receptor

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Abstract

The CGRP (calcitonin gene-related peptide) receptor is a family B GPCR (G-protein-coupled receptor). It consists of a GPCR, CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity modifying protein 1). RAMP1 is needed for CGRP binding and also cell-surface expression of CLR. CLR is an example of a family B GPCR. Unlike family A GPCRs, little is known about how these receptors are activated by their endogenous ligands. This review considers what is known about the activation of family B GPCRs and then considers how this might be applied to CLR, particularly in light of new knowledge of the crystal structures of family A GPCRs.

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Keywords

610, Q Science (General), Crystallography, X-Ray, Protein Binding, Receptors, Calcitonin Gene-Related Peptide

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