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Biology of the Cell
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Biology of the Cell
Article . 2005 . Peer-reviewed
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Biology of the Cell
Article . 2006
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https://dx.doi.org/10.1042/bc2...
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Trafficking mechanism of water channel aquaporin‐2

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2005 English Publisher:WileyJournal:Biology of the Cell, volume 97, pages 885-892 (issn: 0248-4900, eissn: 1768-322X, Copyright policy )
Authors: Yumi, Noda; Sei, Sasaki;

doi: 10.1042/bc20040120

pmid: 16293109

Trafficking mechanism of water channel aquaporin‐2

Abstract

Targeted positioning of the water channel AQP2 (aquaporin‐2) strictly regulates body water homoeostasis. Trafficking of AQP2 to the apical membrane is critical for the reabsorption of water in renal collecting ducts. In addition to the cAMP‐mediated effect of vasopressin on AQP2 trafficking to the apical membrane, other signalling cascades can also induce this sorting. Recently, AQP2‐binding proteins which could regulate this trafficking have been discovered; SPA‐1 (signal‐induced proliferation‐associated gene‐1), a GAP (GTPase‐activating protein) for Rap1, and the cytoskeletal protein actin. This review summarizes recent advances related to the trafficking mechanisms of AQP2.

Related Organizations
Keywords

Aquaporin 2, Vasopressins, GTPase-Activating Proteins, Nuclear Proteins, Cyclic AMP-Dependent Protein Kinases, Actins, Clathrin, Endocytosis, Protein Transport, Animals, Homeostasis, Humans, Kidney Tubules, Collecting, Phosphorylation, Cytoskeleton, Signal Transduction

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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 68
    popularity
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    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
68
Top 10%
Top 10%
Top 10%
bronze