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Thermodynamic origins of two-component multiphase condensates of proteins

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2023Embargo end date: 10 Jan 2023 United Kingdom English Publisher:Royal Society of Chemistry (RSC)Journal:Chemical Science, volume 14, pages 1,820-1,836 (issn: 2041-6520, eissn: 2041-6539, Copyright policy )Funded by:EC | InsideChromatin, UKRI | Peta-5: A National Facili...
Authors: Chew, Pin Yu; Joseph, Jerelle A; Collepardo-Guevara, Rosana; Reinhardt, Aleks;

doi: 10.1039/d2sc05873a , 10.17863/cam.92590 , 10.17863/cam.95363 , 10.17863/cam.93169

pmid: 36819870

pmc: PMC9931050

Thermodynamic origins of two-component multiphase condensates of proteins

Abstract

We develop a computational method integrating a genetic algorithm with a residue-level coarse-grained model of intrinsically disordered proteins in order to uncover the molecular origins of multiphase condensates and enable their controlled design.

Country
United Kingdom
Related Organizations
Keywords

Chemistry, 34 Chemical Sciences, 1.1 Normal biological development and functioning, 1 Underpinning research, Generic health relevance

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    selected citations
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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 19
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
19
Top 10%
Average
Top 10%
Green
gold