The polyketide backbone of thiolactomycin is assembled by an unusual iterative polyketide synthase

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2017 English Publisher:Royal Society of Chemistry (RSC)Journal:Chemical Communications, volume 53, pages 2,182-2,185 (issn: 1359-7345, eissn: 1364-548X,

Copyright policy )Funded by:UKRI | Synthetic probes of natur..., NSERC | unidentified

Authors: Marie E. Yurkovich; Robert Jenkins; Yuhui Sun; Manuela Tosin; Peter F. Leadlay;

doi: 10.1039/c6cc09934c

pmid: 28124037

The polyketide backbone of thiolactomycin is assembled by an unusual iterative polyketide synthase

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Abstract

Thiotetronate polyketide assembly by an unusual iterative synthase is reconstructedvia in vitroenzymology and chemical probes.

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Keywords

RM, Thiophenes, QP, Recombinant Proteins, QR, Anti-Bacterial Agents, Biosynthetic Pathways, Multigene Family, Actinomycetales, QD, Polyketide Synthases

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