Diversity-oriented synthesis; a spectrum of approaches and results
Copyright policy )Diversity-oriented synthesis; a spectrum of approaches and results
Since our emerging area article, diversity-oriented synthesis (DOS), which aims to prepare efficiently collections of skeletally diverse small molecules, has developed in the synthetic approaches it employs. This article describes three general strategies, highlighting some successful examples. The utility of DOS, in the interrogation of chemical space and in the identification of novel biologically active lead compounds, is also discussed.
- University of Cambridge United Kingdom
- Leiden University Netherlands
Small Molecule Libraries, Models, Chemical, Molecular Structure, Pharmacogenetics, Chemistry, Pharmaceutical, Drug Design, Molecular Conformation, Combinatorial Chemistry Techniques, Humans, Cyclooxygenase Inhibitors, Software
Small Molecule Libraries, Models, Chemical, Molecular Structure, Pharmacogenetics, Chemistry, Pharmaceutical, Drug Design, Molecular Conformation, Combinatorial Chemistry Techniques, Humans, Cyclooxygenase Inhibitors, Software
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