Regioselective Halogenation of 1,4-Benzodiazepinones via CH Activation

descriptionPublicationkeyboard_double_arrow_right Article 16 Jul 2015 France English Publisher:Springer Science and Business Media LLCJournal:Scientific Reports, volume 5 (eissn: 2045-2322,

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Authors: Abdelkafi, Hajer; Cintrat, Jean-Christophe;

APC: 1,398 EUR

doi: 10.1038/srep12131

pmid: 26179245

pmc: PMC4503988

Regioselective Halogenation of 1,4-Benzodiazepinones via CH Activation

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Abstract

AbstractThis article reports an efficient CH activation process for regioselective halogenation of 1,4-benzodiazepinones. Direct halogenation with NXS (X = Br, I) affords halogenated benzodiazepinones on the central aromatic ring whereas catalyst (Pd(OAc)2) controlled CH activation furnishes regioselectively ortho halogenated benzodiazepinones on the phenyl side chain.

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Keywords

[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], Article

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