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Nature Structural & Molecular Biology
Article . 2014 . Peer-reviewed
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Article . 2014
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https://dx.doi.org/10.1038/nsm...
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Histone H2A monoubiquitination promotes histone H3 methylation in Polycomb repression

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 18 May 2014 Netherlands English Publisher:Springer Science and Business Media LLCJournal:Nature Structural & Molecular Biology, volume 21, pages 569-571 (issn: 1545-9993, eissn: 1545-9985, Copyright policy )Funded by:EC | 4DCELLFATE
Authors: Reinhard Kalb; Sebastian Latwiel; H Irem Baymaz; Pascal W T C Jansen; Christoph W Müller; Michiel Vermeulen; Jürg Müller;

doi: 10.1038/nsmb.2833

pmid: 24837194

handle: https://repository.ubn.ru.nl/handle/2066/135385 , 2066/135385 , 11858/00-001M-0000-0019-DBED-A

Histone H2A monoubiquitination promotes histone H3 methylation in Polycomb repression

Abstract

A key step in gene repression by Polycomb is trimethylation of histone H3 K27 by PCR2 to form H3K27me3. H3K27me3 provides a binding surface for PRC1. We show that monoubiquitination of histone H2A by PRC1-type complexes to form H2Aub creates a binding site for Jarid2-Aebp2-containing PRC2 and promotes H3K27 trimethylation on H2Aub nucleosomes. Jarid2, Aebp2 and H2Aub thus constitute components of a positive feedback loop establishing H3K27me3 chromatin domains.

Country
Netherlands
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Keywords

Histones, Proteomics and Chromatin Biology, Ubiquitination, Animals, Polycomb-Group Proteins, Drosophila, Epigenetic Repression, Methylation

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 401
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 1%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 0.1%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
401
Top 1%
Top 1%
Top 0.1%
Green
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Netherlands Research Portal