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Nature Reviews Nephrology
Article . 2014 . Peer-reviewed
License: Springer TDM
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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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Article . 2015
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Nature Reviews Nephrology
Article . 2015
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Differentiation of parietal epithelial cells into podocytes

descriptionPublicationkeyboard_double_arrow_right Article 25 Nov 2014 English Publisher:Springer Science and Business Media LLCJournal:Nature Reviews Nephrology, volume 11, pages 7-8 (issn: 1759-5061, eissn: 1759-507X, Copyright policy )
Authors: LAZZERI, ELENA; ROMAGNANI, PAOLA;

doi: 10.1038/nrneph.2014.218

pmid: 25421831

handle: 2158/955342

Differentiation of parietal epithelial cells into podocytes

Abstract

A new study demonstrates that knockdown of miR-193a in human parietal epithelial cells induces their differentiation into podocytes. Inhibition of miR-193a in a model of nephrotoxic nephritis resulted in reduced proteinuria and crescent formation. These data suggest that promoting differentiation of parietal progenitors into podocytes has potential therapeutic relevance.

Related Organizations
Keywords

MicroRNAs, Gene Expression Regulation, Glomerulosclerosis, Focal Segmental, Podocytes, Cell Transdifferentiation, Animals, Humans, kidney; renal stem cells

  • BIP!
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    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 20
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
20
Top 10%
Average
Top 10%
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