Regulated transport of the glucose transporter GLUT4
Copyright policy )Regulated transport of the glucose transporter GLUT4
In muscle and fat cells, insulin stimulates the delivery of the glucose transporter GLUT4 from an intracellular location to the cell surface, where it facilitates the reduction of plasma glucose levels. Understanding the molecular mechanisms that mediate this translocation event involves integrating our knowledge of two fundamental processes--the signal transduction pathways that are triggered when insulin binds to its receptor and the membrane transport events that need to be modified to divert GLUT4 from intracellular storage to an active plasma membrane shuttle service.
MESH: Signal Transduction, MESH: Muscles, MESH: Vesicular Transport Proteins, Monosaccharide Transport Proteins, Active, MESH: Biological Transport, Molecular Biology/Biochemistry [q-bio.BM], Vesicular Transport Proteins, Biological Transport, Active, Golgi Apparatus, Muscle Proteins, MESH: Insulin, [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Endosomes, [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Models, Biological, MESH: Muscle Proteins, MESH: Golgi Apparatus, MESH: Models, [SDV.BC.BC] Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Adipocytes, Animals, Humans, Insulin, MESH: Animals, [SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], MESH: Adipocytes, MESH: Humans, Glucose Transporter Type 4, Muscles, Membrane Proteins, Biological, Molecular Biology/Molecular biology, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, MESH: Endosomes, MESH: Monosaccharide Transport Proteins, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, MESH: Glucose Transporter Type 4, MESH: Membrane Proteins, SNARE Proteins, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, MESH: SNARE Proteins, Signal Transduction
MESH: Signal Transduction, MESH: Muscles, MESH: Vesicular Transport Proteins, Monosaccharide Transport Proteins, Active, MESH: Biological Transport, Molecular Biology/Biochemistry [q-bio.BM], Vesicular Transport Proteins, Biological Transport, Active, Golgi Apparatus, Muscle Proteins, MESH: Insulin, [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Endosomes, [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Models, Biological, MESH: Muscle Proteins, MESH: Golgi Apparatus, MESH: Models, [SDV.BC.BC] Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Adipocytes, Animals, Humans, Insulin, MESH: Animals, [SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], MESH: Adipocytes, MESH: Humans, Glucose Transporter Type 4, Muscles, Membrane Proteins, Biological, Molecular Biology/Molecular biology, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, MESH: Endosomes, MESH: Monosaccharide Transport Proteins, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, MESH: Glucose Transporter Type 4, MESH: Membrane Proteins, SNARE Proteins, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, MESH: SNARE Proteins, Signal Transduction
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