Rett syndrome: a complex disorder with simple roots
Copyright policy )Rett syndrome: a complex disorder with simple roots
Rett syndrome (RTT) is a severe neurological disorder caused by mutations in the X-linked gene MECP2 (methyl-CpG-binding protein 2). Two decades of research have fostered the view that MeCP2 is a multifunctional chromatin protein that integrates diverse aspects of neuronal biology. More recently, studies have focused on specific RTT-associated mutations within the protein. This work has yielded molecular insights into the critical functions of MeCP2 that promise to simplify our understanding of RTT pathology.
- University of Edinburgh United Kingdom
- Wellcome Centre for Cell Biology United Kingdom
Mice, Knockout, Neurons, Methyl-CpG-Binding Protein 2, Models, Neurological, Brain, DNA, Disease Models, Animal, Mice, Gene Expression Regulation, Mutation, Rett Syndrome, Trans-Activators, Animals, Humans, Protein Binding
Mice, Knockout, Neurons, Methyl-CpG-Binding Protein 2, Models, Neurological, Brain, DNA, Disease Models, Animal, Mice, Gene Expression Regulation, Mutation, Rett Syndrome, Trans-Activators, Animals, Humans, Protein Binding
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