Small island, big genetic discoveries

descriptionPublicationkeyboard_double_arrow_right Article 28 Oct 2015 English Publisher:Springer Science and Business Media LLCJournal:Nature Genetics, volume 47, pages 1,224-1,225 (issn: 1061-4036, eissn: 1546-1718,

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Authors: Guillaume, Lettre; Joel N, Hirschhorn;

doi: 10.1038/ng.3426

pmid: 26506900

Small island, big genetic discoveries

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Abstract

Three new studies have identified new genes and sequence variants implicated in blood lipids, inflammatory markers, hemoglobin levels and adult height variation in Sardinia. These reports highlight the usefulness of large-scale genotype imputation based on whole-genome sequencing, particularly in isolated populations, in studying the genetics of complex human phenotypes.

Related Organizations

Boston Children's Hospital
United States
Broad Institute
United States
Montreal Heart Institute
Canada
Harvard University
United States
University of Montreal
Canada

Keywords

Adult, Islands, Genotype, Geography, Genetic Variation, Lipids, Body Height, Hemoglobins, Genetics, Population, Phenotype, Italy, Humans, Genetic Association Studies

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