The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity
Copyright policy )The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity
ATP-binding cassette transporter G1 (ABCG1) promotes cholesterol efflux from cells and regulates intracellular cholesterol homeostasis. Here we demonstrate a role of ABCG1 as a mediator of tumour immunity. Abcg1(-/-) mice have dramatically suppressed subcutaneous MB49-bladder carcinoma and B16-melanoma growth and prolonged survival. We show that reduced tumour growth in Abcg1(-/-) mice is myeloid cell intrinsic and is associated with a phenotypic shift of the macrophages from a tumour-promoting M2 to a tumour-fighting M1 within the tumour. Abcg1(-/-) macrophages exhibit an intrinsic bias towards M1 polarization with increased NF-κB activation and direct cytotoxicity for tumour cells in vitro. Overall, our study demonstrates that the absence of ABCG1 inhibits tumour growth through modulation of macrophage function within the tumour, and illustrates a link between cholesterol homeostasis and cancer.
bladder carcinoma, cell organelle, animal cell, cholesterol homeostasis, Mice, homeostasis, Homeostasis, macrophage function, Melanoma, ATP Binding Cassette Transporter, Subfamily G, Member 1, Mice, Knockout, Mus, apoptosis, Flow Cytometry, inhibition, immunoglobulin enhancer binding protein, tumor growth, Cholesterol, cytotoxicity, tumor, in vitro study, organic compound, phenotype, Lipoproteins, animal experiment, 610, tumor cell, Real-Time Polymerase Chain Reaction, Article, Fluorescence, cholesterol transport, Cell Line, Tumor, 616, cancer, Animals, mouse, ABC transporter G1, nonhuman, Macrophages, Carcinoma, melanoma B16, immunity, tumor immunity, Mice, Inbred C57BL, Urinary Bladder Neoplasms, ATP-Binding Cassette Transporters, bone marrow cell
bladder carcinoma, cell organelle, animal cell, cholesterol homeostasis, Mice, homeostasis, Homeostasis, macrophage function, Melanoma, ATP Binding Cassette Transporter, Subfamily G, Member 1, Mice, Knockout, Mus, apoptosis, Flow Cytometry, inhibition, immunoglobulin enhancer binding protein, tumor growth, Cholesterol, cytotoxicity, tumor, in vitro study, organic compound, phenotype, Lipoproteins, animal experiment, 610, tumor cell, Real-Time Polymerase Chain Reaction, Article, Fluorescence, cholesterol transport, Cell Line, Tumor, 616, cancer, Animals, mouse, ABC transporter G1, nonhuman, Macrophages, Carcinoma, melanoma B16, immunity, tumor immunity, Mice, Inbred C57BL, Urinary Bladder Neoplasms, ATP-Binding Cassette Transporters, bone marrow cell
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