Whole genome analysis of a schistosomiasis-transmitting freshwater snail
Copyright policy )Whole genome analysis of a schistosomiasis-transmitting freshwater snail
AbstractBiomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control. Here, we characterize the genome of Biomphalaria glabrata, a lophotrochozoan protostome, and provide timely and important information on snail biology. We describe aspects of phero-perception, stress responses, immune function and regulation of gene expression that support the persistence of B. glabrata in the field and may define this species as a suitable snail host for S. mansoni. We identify several potential targets for developing novel control measures aimed at reducing snail-mediated transmission of schistosomiasis.
- University of Notre Dame United States
- Lawrence University United States
- Harvard University United States
- George Washington University United States
- National Institutes of Health United States
MESH: Schistosoma mansoni, QH301 Biology, INTERMEDIATE HOST, Pheromones, MESH: Animals, DNA sequencing, MESH: Pheromones, INVERTEBRATE, Schistosoma mansoni, genome informatics, MESH: DNA Transposable Elements, MESH: Fresh Water, Science & Technology - Other Topics, [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Infection, Biomphalaria/immunology, 570, Evolution, Physiological, Science, 610, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, MESH: Host-Parasite Interactions, Article, Schistosomiasis mansoni/transmission*, Evolution, Molecular, SDG 3 - Good Health and Well-being, Genetics, genome, BIOMPHALARIA-GLABRATA, Science & Technology, RECOGNITION, 500, Molecular, DNA, FoR multidisciplinary, [SDV.BA.ZI]Life Sciences [q-bio]/Animal biology/Invertebrate Zoology, Vector-Borne Diseases, biomphalaria snails, Biotechnology and Biological Sciences Research Council (BBSRC), INNATE IMMUNITY, [SDV.BA.ZI] Life Sciences [q-bio]/Animal biology/Invertebrate Zoology, Digestive Diseases, biological, Genome*, Proteome, Fresh Water, Genome informatics, Biomphalaria/parasitology*, MESH: Biomphalaria/parasitology*, Biomphalaria/genetics*, ACTIN GENES, BB/H022597/1, Genome, Biomphalaria, snail biology, schistosomiase, Q, MESH: Gene Expression Regulation, MESH: Proteome, Multidisciplinary Sciences, Infectious Diseases, MESH: Animal Communication, Sequence Analysis, [SDV.MP.PAR] Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, MANSONI, MESH: Stress, Stress, Host-Parasite Interactions, MESH: Sequence Analysis, QH301, Stress, Physiological, MESH: Schistosomiasis mansoni/transmission*, MESH: Evolution, Journal Article, MESH: Biomphalaria/genetics*, Animals, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, blood fluke, Molecular Biology/Genomics [q-bio.GN], COMPLEXITY, MESH: Genome*, escargot aquatique, zoology, Human Genome, Sequence Analysis, DNA, EVOLUTION, Schistosomiasis mansoni, Animal Communication, Good Health and Well Being, Gene Expression Regulation, MESH: Biomphalaria/immunology, DNA Transposable Elements, VERTEBRATE, Zoology
MESH: Schistosoma mansoni, QH301 Biology, INTERMEDIATE HOST, Pheromones, MESH: Animals, DNA sequencing, MESH: Pheromones, INVERTEBRATE, Schistosoma mansoni, genome informatics, MESH: DNA Transposable Elements, MESH: Fresh Water, Science & Technology - Other Topics, [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Infection, Biomphalaria/immunology, 570, Evolution, Physiological, Science, 610, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, MESH: Host-Parasite Interactions, Article, Schistosomiasis mansoni/transmission*, Evolution, Molecular, SDG 3 - Good Health and Well-being, Genetics, genome, BIOMPHALARIA-GLABRATA, Science & Technology, RECOGNITION, 500, Molecular, DNA, FoR multidisciplinary, [SDV.BA.ZI]Life Sciences [q-bio]/Animal biology/Invertebrate Zoology, Vector-Borne Diseases, biomphalaria snails, Biotechnology and Biological Sciences Research Council (BBSRC), INNATE IMMUNITY, [SDV.BA.ZI] Life Sciences [q-bio]/Animal biology/Invertebrate Zoology, Digestive Diseases, biological, Genome*, Proteome, Fresh Water, Genome informatics, Biomphalaria/parasitology*, MESH: Biomphalaria/parasitology*, Biomphalaria/genetics*, ACTIN GENES, BB/H022597/1, Genome, Biomphalaria, snail biology, schistosomiase, Q, MESH: Gene Expression Regulation, MESH: Proteome, Multidisciplinary Sciences, Infectious Diseases, MESH: Animal Communication, Sequence Analysis, [SDV.MP.PAR] Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, MANSONI, MESH: Stress, Stress, Host-Parasite Interactions, MESH: Sequence Analysis, QH301, Stress, Physiological, MESH: Schistosomiasis mansoni/transmission*, MESH: Evolution, Journal Article, MESH: Biomphalaria/genetics*, Animals, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, blood fluke, Molecular Biology/Genomics [q-bio.GN], COMPLEXITY, MESH: Genome*, escargot aquatique, zoology, Human Genome, Sequence Analysis, DNA, EVOLUTION, Schistosomiasis mansoni, Animal Communication, Good Health and Well Being, Gene Expression Regulation, MESH: Biomphalaria/immunology, DNA Transposable Elements, VERTEBRATE, Zoology
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